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Measurement and Results - Internal standard selection for ICP-MS
Do you have an overview of which elements are best suited as internal standards with ionization potential, mass etc. in mind? I am currently analyzing the following elements using your custom stock solution: Na, K, Li, Al, Ca, Fe, Ti, Co, Cr, Cu, Ni, Mn, B, Mg, P, Ge, Zr, U, Ce, Nd, Th, La, Mo, Zn, Sr, Y, Ba, V and Bi. Do you have a recommendation for which internal standards to use for these? Currently using Ga for Na, Mg, Al, K, Ca40, V, Cr, Mn, Fe56, Co, Ni, Zn and Ge in DRC mode. And using Rh for: Li, B, P, Ti, Cu63, Sr, Y, Zr, Ba, La, Ce and Nd. And Re for Bi, Th and U in standard mode.
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For Al and the low mass alkali elements (e.g., Li, Na, and K) 6Li is a good choice (it is possible to measure Li using 7Li for quantification and 6Li for internal standardization). For alkaline earths such as Ca and Mg, as well as first row transition metals (Ti through ~Cu), Sc works well for almost any sample that isn’t rare-earth enriched. The ionization potential of Zn is similar to As, so if your solutions are chloride-free As could be a good choice for Zn. In the 80-120 mass range, Rh is probably the best choice based upon your analytes of interest. For Ba and the rare earths (La, Ce, and Nd), a good internal standard would be Tb, as it’s closer in ionization potential than Rh and a closer in mass. For the highest masses (Bi, Th, and U) Re is a good IS, as it avoids the precious metals like Au, which require some HCl for stability and that can tend to ‘stick’ in the sample introduction system. |