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Measurement and Results - Metal analysis in HBr by ICP

 
I work where we manufacture radionuclidic pharmaceuticals. Lately we've encountered metal contamination in some of our manufacturing processes and in order to pinpoint the source of contamination we'll be performing a study where the cleaning solution will be analyzed on the ICP at various points of the manufacturing process. Per our procedure, HBr will be used as a cleaning/ rinse solution. Is it possible to analyze a diluted (10%) concentration of HBr on the ICP? We're mainly looking for Zinc, Iron, and Nickel. Not so much for an exact concentration but for identification purposes only. I know that bromine does not yield good recoveries on the ICP but will HBr cause harm to the instrument or create a high background preventing some elements of interest from being detected?
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admin Total posts: 529
Assuming the ICP sample introduction system is compatible with HBr, analyzing a dilute (10%) HBr solution should not present any greater concerns than would be expected when analyzing any strong mineral acids such as hydrochloric acid. The primary concerns would be fumes attacking electronic components (similar to HCl) and degradation of the ICP interface/cones. If using ICP-MS, the use of Pt cones might be necessary as Ni is an element of interest, and if mass spec is the technique then there should be no issues with background or interferences when measuring the transition metals listed.
Posted: 09/05/18 23:14:11

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