Internal Standardization and Isotope Dilution

Overview

Part 11 of this series is a continuation of discussions around the recommendations made in part 10. Please reference Part 10: Calibration Curve and Standard Additions Techniques before you proceed.

Discussion (c and d) - For the sake of convenience, recommendations (c) and (d) are reprinted from Part 10 as follows:

Recommendation (c) - With unknown sample matrices, matching is not possible and is most accurately dealt with using the technique of standard additions. However, this approach is slow as compared to the calibration curve technique with the use of internal standardization.

Recommendation (d) - The use of internal standardization is very effective in many cases but may introduce--or not correct for--all errors. This statement does not apply to isotope dilution ICP-MS that is considered to be a primary analytical technique.

Matrix effects are arguably the subtlest danger to the ICP-OES analyst. Slight differences in the matrix can cause a considerable systematic error. The most common calibration technique options for ICP measurements are calibration curve and standard additions.

Was this helpful?  Tell a Friend | Let us know